SSU72 Antibody, Biotin conjugated

Code CSB-PA865091LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SSU72 Polyclonal antibody
Uniprot No.
Target Names
SSU72
Alternative Names
CTD phosphatase SSU72 antibody; HSPC182 antibody; Hypothetical protein FLJ10947 antibody; PNAS-120 antibody; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 antibody; ssu72 antibody; Ssu72 RNA polymerase II CTD phosphatase homolog antibody; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) antibody; SSU72_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human RNA polymerase II subunit A C-terminal domain phosphatase SSU72 protein (1-194AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.
Gene References into Functions
  1. a hand-off model in which Ssu72 mediates a conformational transition in TFIIB, accounting for the role of Ssu72 in transcription reinitiation, gene looping, and promoter-terminator cross-talk. PMID: 29158257
  2. Aurora B kinase directly targets Ssu72 phosphatase for regulation of sister chromatid cohesion during early mitosis. PMID: 24149858
  3. The pSer7 phosphatase activity of Ssu72 is approximately 4000-fold lower than its pSer5 phosphatase activity toward a peptide substrate PMID: 23070812
  4. Data suggest that Ssu72 is a novel cohesin-binding protein capable of regulating cohesion between sister chromatid arms. PMID: 20818333
  5. crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser 5 phosphatase Ssu72 and a CTD Ser 5 phosphopeptide PMID: 20861839
  6. Molecular cloning and characterization of functions of human ssu72. PMID: 15659578

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Subcellular Location
Nucleus. Cytoplasm. Note=Predominantly in the cytosol.
Protein Families
SSU72 phosphatase family
Database Links

HGNC: 25016

OMIM: 617680

KEGG: hsa:29101

STRING: 9606.ENSP00000291386

UniGene: Hs.30026

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